ADI-SMCS offers a full K-12 curriculum which also includes a preparatory for Kinder. Program of studies for Kindergarten up to Grade 10 are consistent with the Department of Education's requirements which generally consists of English, Filipino, Social Studies, Mathematics, Science, Technology and Livelihood Education (TLE), and Physical Education and Music (PEM). To further advance the school's vision and mission, Chinese Language and Culture as well as Christian Life Education are also part of the core curriculum.
The Senior High School (Grades 11 -12) offers two Strands under the Academic Track, namely: Science, Technology, Engineering, and Mathematics (STEM) and Accountancy, Business, and Management (ABM). It covers all the core, applied, and specialized subjects required by the Department of Education. As a Jesuit, Chinese-Filipino mission school, the Ateneo SHS likewise includes Ignatian Spirituality and the integration of Christian Life Education (CLE) in the curriculum.